Advances on relationship between insulin receptor substrate-1 and insulin resistance in liver cirrhosis.
- Author:
Bing-quan CHEN
1
;
Yan-feng ZHOU
Author Information
1. Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Insulin;
metabolism;
Insulin Receptor Substrate Proteins;
metabolism;
physiology;
Insulin Resistance;
Liver Cirrhosis;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2012;41(3):339-344
- CountryChina
- Language:Chinese
-
Abstract:
Liver cirrhosis (LC) and insulin resistance (IR) are closely correlated, clinically presenting hyperglycemia, hyperinsulinism, hyperlipidemia and high cytokines levels, however, the underlying mechanism is not completely clear. Recent reports show that insulin receptor substrate-1 (IRS-1) is associated with IR in LC. IRS-1 plays a pivotal role on insulin signal transduction; it changes insulin signaling by up-or down-regulating of protein presentation, post-translational modification and subcellular localization of proteins, particularly in phosphorylation/dephosphorylation of post-translational modification. Furthermore, LC with different etiology may have different mechanism of IRS-1 effect on IR.
