Nrf2 as a chemoprevention target in gastrointestinal carcinoma.
- Author:
Peng GAO
1
;
Xiu-wen TANG
;
Xiu-jun WANG
Author Information
1. Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anticarcinogenic Agents;
pharmacology;
Antioxidants;
metabolism;
Chemoprevention;
Digestive System Neoplasms;
genetics;
metabolism;
prevention & control;
Humans;
NF-E2-Related Factor 2;
genetics;
metabolism;
Oxidative Stress;
drug effects;
Response Elements;
genetics;
Signal Transduction;
drug effects
- From:
Journal of Zhejiang University. Medical sciences
2012;41(4):453-463
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal tract carcinoma is one of the leading causes of cancer-related death in China. Chemoprevention has been considered as a potential approach to control this type of disease. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that protects cells from oxidative/electrophilic stresses by activating the expression of a battery of cytoprotective genes through the antioxidant response element (ARE). Recently, Nrf2 has emerged as a novel target for chemoprevention. Several natural or synthetic chemicals, which activate Nrf2/ARE signaling pathway, have showed effect in animal models, and promises in many ongoing clinical trials. This review summarizes the recent findings on the regulation of Nrf2/ARE signaling pathway, and the developments in both preclinical and clinical studies.
