Type I interferon and bacterial infection.
- Author:
Ran DIAO
1
;
Feng XU
;
Xuan-ding WANG
Author Information
1. Department of Respiratory Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bacterial Infections;
immunology;
Humans;
Immunity, Innate;
Interferon Type I;
immunology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2012;41(4):464-468
- CountryChina
- Language:Chinese
-
Abstract:
Interferons (IFNs) are cytokines playing an important role in immune responses. Interferons are classified into two distinct types according to specific interferon receptors(IFNR). Type I IFNs include IFN-α and IFN-β, whereas IFN-γ is type II IFN. It is well known that type I IFNs have important roles in the host defense against viruses through activation of interferon receptor A (IFNAR). However, many recent studies have also demonstrated that type I IFNs have effects on immune responses to bacterial infection. This review focuses on the immune regulation of type I IFN-mediated signal pathways in bacterial infections such as Listeria monocytogenes, Streptococcus, Mycobacterium tuberculosis, Bacillus anthracis, Legionella, Pseudomonas aeruginosa and others.
