A case-control study on risk factors of female breast cancer in Zhejiang province.
- Author:
Xue-ying YAO
1
;
Shan-shan NI
;
Jun ZHOU
;
Hui-yong HU
;
Li-li LI
;
Fang WAN
;
Yi-ke WANG
;
Yi-ding CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; etiology; Case-Control Studies; China; epidemiology; Female; Humans; Logistic Models; Multivariate Analysis; Risk Factors
- From: Journal of Zhejiang University. Medical sciences 2012;41(5):512-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the risk factors on female breast cancer in Zhejiang province.
METHODSA case-control study was conducted in 200 cases of female breast cancer with histopathological diagnosis and 200 matched controls from Zhejiang province.
RESULTSUnivariate conditional logistic regression showed that family history of malignant tumor and breast cancer, housing decoration in last 10 years, mammary hyperplasia, adverse life events, bra with steel rings, sleeping with bra, high fat and pickle intake, poor sleep were positively related to breast cancer; whereas environmental friendly decoration materials, long decoration time interval, workplace condition, more lactation and parity, high fruits intake, sufficient sleep were negatively related to breast cancer. Multivariate conditional logistic regression analysis showed that the risk factors included family history of other tumors [odds ratio (OR)= 1.571,95% confidence interval(CI):1.029-2.396],mammary hyperplasia (OR=3.066,95%CI:1.834-5.126), job-related life events (OR=4.575,95%CI:1.690-12.390),the death of a loved one (OR=2.555,95%CI:1.475-4.424), wearing bra at night (OR=1.902,95%CI:1.177-3.072),high fat intake (OR=2.709,95%CI:1.546-4.749) and salted food (OR=2.460,95%CI:1.300-4.653). Factors as environmental friendly decoration materials (OR=0.517,95%CI:0.339-0.789),workplaces condition (OR=0.430,95%CI:0.243-0.762),more lactation (OR=0.109,95%CI:0.013-0.896),enough sleep (OR=0.424,95%CI:0.205-0.880) were protective factors.
CONCLUSIONHereditary,psychological factors,lifestyle,environment and diet related factors are significantly associated with risk of breast cancer.