Effect of Helicobacter pylori infection on platelet activation and coagulation function in patients with acute cerebral infarction.
- Author:
Hai-qin WU
1
;
Yan TANG
;
Xin ZHANG
;
Xuan-hui WEI
;
Hu-qing WANG
;
Wen-ting ZHANG
;
Gui-lian ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antibodies, Bacterial; blood; Antigens, Bacterial; metabolism; Bacterial Proteins; metabolism; Blood Coagulation; Case-Control Studies; Cerebral Infarction; blood; microbiology; Female; Helicobacter Infections; blood; complications; Helicobacter pylori; metabolism; pathogenicity; Humans; Immunoglobulin G; blood; Male; Middle Aged; P-Selectin; blood; Platelet Activation
- From: Journal of Zhejiang University. Medical sciences 2012;41(5):547-552
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Helicobacter pylori (Hp) on platelet activation and coagulation function in patients with acute cerebral infarction.
METHODSSixty-six patients with acute cerebral infarction and 50 health individuals were enrolled in the study. Hp antibody,expression of CD62p on platelets and clotting indexes were measured and compared between two groups.
RESULTSThe positive rate of Hp-IgG and Hp-CagA in cerebral infarction patients were higher than that in controls (P<0.05). The positive rate of CD62p in patients with positive Hp-IgG and Hp-CagA was significantly higher than that in negative patients and also controls (P<0.05). The APTT and TT were lower and FIB was higher in patients with positive Hp antibody than those in patients with negative Hp antibody (P<0.05),but there was no difference in PT,PTR and INR (P>0.05).
CONCLUSIONHp infection can activate platelets and affect coagulation function,which may be involved in the development of cerebral infarction.
