Research progress of protein tyrosine phosphatase SHP-2.
- Author:
Hong-ke CAI
1
;
Yong-chuan DENG
Author Information
1. Department of Surgical Oncology, Zhejiang University School of Medicine, Hangzhou, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Protein Tyrosine Phosphatase, Non-Receptor Type 11;
chemistry;
metabolism;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2012;41(5):581-585
- CountryChina
- Language:Chinese
-
Abstract:
The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.
