Ubiquitination of recombinant adeno-associated viral vector and its application.
- Author:
Qi-zhao WANG
1
;
Ying-hui LU
;
Yong DIAO
;
Rui-an XU
Author Information
1. Institute of Molecular Medicine, Huaqiao University, Quanzhou, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Dependovirus;
genetics;
metabolism;
Genetic Vectors;
genetics;
metabolism;
Humans;
Transduction, Genetic;
Ubiquitin;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2012;41(5):586-591
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant adeno-associated virus (rAAV) has been widely used as vector for gene therapy. However, the effectiveness of gene therapy based on rAAV needs to be further improved. Enhancement of the transduction efficiency is one of the most important fields for rAAV-based gene therapy. Recent results have showed that the ubiquitin-proteasome system plays an important role in the trafficking of rAAV vector in cytoplasm, and regulation of its function may significantly improve the transduction efficiency of rAAV vector in various types of cells and tissues.
