Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis.
- Author:
Shi-zhuo WANG
1
;
Yun-feng ZHAO
1
;
Jia-yi SUN
1
;
Xing-jie GUO
1
Author Information
- Publication Type:Journal Article
- MeSH: Cetirizine; analysis; Electrophoresis, Capillary; methods; Stereoisomerism; Tablets
- From: Journal of Zhejiang University. Medical sciences 2014;43(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis.
METHODSThe effects of pH and the concentrations of sulfated-Β-cyclodextrin (S-Β-CD) and buffer salt on chiral resolution were examined with S-Β-CD as chiral selector.
RESULTSA good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-Β-CD.
CONCLUSIONThe method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets.
