Research progress on biological toxicity of zinc oxide nanoparticle and its mechanism.
- Author:
Xia YANG
1
;
Mi-zu JIANG
1
Author Information
1. Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China).
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Metal Nanoparticles;
toxicity;
Zinc Oxide;
toxicity
- From:
Journal of Zhejiang University. Medical sciences
2014;43(2):218-226
- CountryChina
- Language:Chinese
-
Abstract:
Zinc oxide nanoparticle (nano-ZnO) has a size between 1 and 100 nm. Nano-ZnO has some special effects, such as small size effect, surface effect, quantum size effect, which makes it different from the ordinary ZnO, and is widely used in rubber industry, food processing, cosmetics and pharmaceutical fields. It has been reported that nano-ZnO has toxic effects in vitro and in vivo, but the mechanism of toxicity is still unclear. Therefore, it is important to evaluate the safety nano-ZnO by studying its biological toxic effects and related mechanisms. In this paper, we summarize the characterization, ingestion pathway, metabolism, systematic toxicity of nano-ZnO and its mechanisms, which may provide us with new strategy for the toxic research of nano-ZnO.
