Histopathological Changes in Internal Organs atter Administration of Amphotericin B.
- Author:
Yoon Kee PARK
;
Sung Nack LEE
;
Jae Yun RO
- Publication Type:Original Article
- MeSH:
Acne Vulgaris;
Amphotericin B*;
Animals;
Darier Disease;
Hepatocytes;
Ichthyosis;
Keratinocytes;
Liver;
Metaplasia;
Mitochondria;
Necrosis;
Pancreas;
Psoriasis;
Rats;
Ribosomes;
Skin Diseases;
Tretinoin;
Vacuoles;
Vitamin A;
Vitamins
- From:Korean Journal of Dermatology
1980;18(6):503-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vitamin A and its metabolite, retinoic acid, have been recommended for the treatment of psoriasis, ichthyosis, acne vulgaris and Darier's disease which resulted from abaormal regulatory function of keratinocytes. In recent years retinoic acid analogs (retinoids) have been synthesized and shown to be more potent and less toxic than retinoic acid. Since these drugs are therapeutically effective for skin diseases, only with longterm adminiatration of large doses, their toxicities must be seriously considered. The liver is the main site for both storage and excretion of vitamin A and ita derivatives, which may produce injury to the liver and other organs as a result of excess of lysosomal enzyme control. Fatty vacuoles, infiltration of inflammatory cells, focal necrosis, increase in lysosomal enzymes, distension of the RER, decrease in the ribosomes, swelling of the mitochondria, and proliferation of the SER within the hepatocytes have been observed in livers of vitamin A- as well as retinoic acid-treated rats. Its excess may also cause mucous metaplasia of secretory cells of the pancreas. (countinued...)
