Two-year observation of the clinical efficacy in treating chronic hepatitis B Patients with Ganxian recipe and lamivudine.
- Author:
Wei-sheng SHEN
1
;
Hong-zhi YANG
;
Qi HONG
;
Yong-qiang ZHANG
;
He-ping XIE
;
Zhuang BIAN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Female; Gene Frequency; Genes, Viral; Hepatitis B Antibodies; blood; Hepatitis B e Antigens; blood; immunology; Hepatitis B virus; genetics; Hepatitis B, Chronic; complications; physiopathology; therapy; virology; Humans; Lamivudine; adverse effects; therapeutic use; Liver; physiopathology; Liver Cirrhosis; pathology; virology; Male; Medicine, Chinese Traditional; methods; Middle Aged; Mutation; Phytotherapy; adverse effects; Plant Preparations; adverse effects; therapeutic use; Reverse Transcriptase Inhibitors; adverse effects; therapeutic use; Treatment Outcome
- From: Chinese journal of integrative medicine 2005;11(1):5-10
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the clinical efficacy of Ganxian recipe (GXR) and lamivudine (LVD) in a two-year treatment of chronic hepatitis B (CHB).
METHODSOne hundred and twenty patients with CHB were randomly divided into the combinedly treated group (combined group) of 40 CHB patients who were treated with GXR combined with LVD. Another 40 CHB patients were treated with LVD alone (WM group), and still another 40 CHB patients were treated with GXR alone (TCM group). All these cases were randomly controlled and observed for two years.
RESULTSComprehensive efficacy: Total effective rate of the combined group (complete response and partial response) was 92.5%, while that of the WM group was 67.5% and TCM group 57.5%, respectively, with the difference between them was significant (P < 0.01); after treatment, the hepatic functions (AST, ALT, SB) of the three groups were all reduced, and the reduction in the combined group was particularly significant in comparison with the WM group or TCM group, P < 0.05 or P < 0.01 respectively, suggesting that the effect in the combined group was better than that in the other two groups; the rate of tyrosine-methionine-aspartate-aspartate (YMDD) virus mutation: it was 7.5% in the combined group, 40.0% in the WM group, and 5.0% in the TCM group; liver fibrosis improvement parameter: after treatment, the results in the combined group got better than those in the other two groups.
CONCLUSIONGXR could inhibit the appearance of YMDD after long-term application of LVD, and combined use has marked synergism.
