Polo like kinase 1 expression and prognostic value in gastric carcinomas.
- Author:
Bin LAN
1
;
Bin-Ya LIU
;
Xue-Hua CHEN
;
Ying QU
;
Xiao-Qing ZHANG
;
Qu CAI
;
Zheng-Gang ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cell Cycle Proteins; genetics; metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Neoplasm Staging; Prognosis; Protein-Serine-Threonine Kinases; genetics; metabolism; Proto-Oncogene Proteins; genetics; metabolism; Stomach Neoplasms; genetics; metabolism; pathology
- From: Chinese Journal of Gastrointestinal Surgery 2007;10(1):70-72
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the expression of polo like kinase 1 (plk1) and to discuss its relationship with the clinicopathological parameters and prognosis in gastric carcinoma.
METHODSPlk1 protein expression levels in 89 cases of resected gastric carcinomas were detected by immunohistochemistry method, the relations between plk1 expression levels and the survival periods were estimated by Kaplan-Meier curve.
RESULTSThe positive rate of plk1 expression in gastric cancer tissues was 42.7% (38/89), significantly higher than that (13.5%) in the adjacent noncancerous tissues (12/89) (P<0.01). The expression levels of plk1 were closely related to tumor differentiation, invasion and TNM stage (P<0.05). Patients with plk1-positive expression had worse prognosis than those with plk1-negative expression in gastric cancer patients (P<0.05).
CONCLUSIONSPlk1 may promote carcinogenesis and gastric cancer development, its overexpression can be a novel marker for diagnosing certain biological behaviours and predicting prognosis in gastric cancer.
