Study of prophylactic intra-iliac and hepatic arterial infusion chemotherapy against pelvic recurrence and liver metastasis after radical resection for rectal cancer.
- Author:
Shi-liang TU
1
;
Jian-hua YUAN
;
Gao-li DENG
;
Zhong-sheng ZHAO
;
Ting-yang HU
;
Quan-jin DONG
;
Hong-feng CAO
;
Zai-yuan YE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Female; Hepatic Artery; Humans; Iliac Artery; Liver Neoplasms; prevention & control; secondary; Male; Middle Aged; Neoplasm Recurrence, Local; prevention & control; Pelvic Neoplasms; prevention & control; secondary; Pelvis; pathology; Rectal Neoplasms; drug therapy; pathology; Survival Rate
- From: Chinese Journal of Gastrointestinal Surgery 2007;10(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of prophylactic intra-iliac and hepatic arterial infusion chemotherapy on pelvic recurrence and liver metastasis after radical resection for rectal cancer.
METHODSEighty-four rectal cancer patients,undergone radical resection on Dukes stage B or C,were randomly assigned to postoperative intra-iliac and hepatic arterial infusion chemotherapy group(group I) and routine vein chemotherapy group(group II). Five-year survival and recurrence rates were compared between the two groups.
RESULTSAmong the 84 rectal cancer patients with radical resection, the 5-year liver metastasis and pelvic recurrence rates were 30.2% (13/43) and 18.6% (8/43) respectively in group II, 17.1% (7/41) and 9.8% (4/41) in group I, the difference was significant between 2 groups (chi(2)=4.31, P<0.05). The mean tumor-free survival time was 26.2 months in group I and 15.8 months in group II (t=5.05, P<0.01), the difference was significant (t=5.05, P<0.01). The five-year survival rate in group I (65.9%) was significantly higher than that in group II (56.5%) (u=8.86, P<0.01). Cox multivariate analysis showed that, compared with those in group II, the relative risks of pelvic recurrence and liver metastasis in group I decreased 20% (coefficient of relative risk: 0.7959), and the five-year mortality also decreased 20% (coefficient of relative risk: 0.8034).
CONCLUSIONProphylactic intra-iliac and hepatic arterial infusion chemotherapy can reduce the rates of pelvic recurrence and liver metastasis after radical resection of rectal cancer.
