Expression of 39 HOX genes in esophageal cancer cell lines.
- Author:
Zhen-dong GU
1
;
Xiao-mei CHEN
;
Wei ZHANG
;
Jin GU
;
Ke-neng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Cell Line, Tumor; Esophageal Neoplasms; genetics; Gene Expression Profiling; Genes, Homeobox; genetics; Humans; Multigene Family; RNA; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Gastrointestinal Surgery 2007;10(4):365-367
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify whether HOX genes can be used as markers of esophageal cancer.
METHODSThe expression of 39 HOX genes in esophageal cancer cell lines was examined. Specific primers were designed and RT- PCR was performed for each HOX gene members in above esophageal cancer cell lines, EC109 and CAES.
RESULTSFifteen out of 39 HOX genes were expressed in esophageal cancer cell lines. They were HOXA2, HOXA7, HOXA9, HOXA10, HOXA13, HOXB7, HOXB9, HOXC4, HOXC5, HOXC6, HOXC8, HOXC9, HOXD9, HOXD10, and HOXD13 respectively. Of them. Eleven genes were overlapped with the ones detected in human esophageal squamous cell carcinoma(ESCC) in our former study.
CONCLUSIONThis study reconfirms our former that some HOX genes are deregulated expressed in ESCC, which provides more positive evidence for their roles in ESCC.
