A Clinical Study of 500 Cases of Breast Cancer.
- Author:
In Sik PARK
1
;
Ja Yun KOO
;
Hy De LEE
;
Woo Hee JUNG
Author Information
1. Department of Surgery, Yonsei University Colleage of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Breast cancer;
Clinical characteristics;
Survival rates
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinoma, Ductal;
Carcinoma, Intraductal, Noninfiltrating;
Carcinoma, Lobular;
Disease-Free Survival;
Female;
Humans;
Liver;
Lung;
Lymph Nodes;
Mastectomy, Modified Radical;
Mastectomy, Segmental;
Neoplasm Metastasis;
Nipples;
Survival Rate
- From:Journal of the Korean Cancer Association
1997;29(6):1061-1068
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the clinical characteristics of breast cancers and its significance. MATERIAL AND METHOD: We evaluated the clinical characteristics of 500 women with breast cancer who were diagnosed and treated by one surgeon between March 1991 and August 1996. RESULTS: The median age was 46.7 years and the most common age group was 40's. The presenting symptoms for most patients were palpable mass (75.2%) followed by abnormal mammographic findings (8.4%), pain (6.3%) and nipple discharges (4.7%), and the duration of symptoms was less than 1 month in 41.4%. Fifty three percent of the 500 cases had T2 lesion (size; 2 to 5 cm). With the increase of tumor size, overall and disease free survival rates (OS, DFS) were decreased. Surgical treatment consisted of modified radical mastectomy (52.8%) and partial mastectomy (33.6%) The most common stage was II (42.3%) and the early breast cancer (stage 0, I, II) was 388cases (78.1%) and the stage were inversely correlated with DFS and OS. The positivity of axillary lymph node was 39.3% and the number of the metastatic lymph nodes was inversely correlated with DFS and OS. The pathologic types were infiltrating ductal carcinoma (83.0%), ductal carcinoma in situ (12.8%), infiltrating lobular carcinoma (1.2%), lobular carcinoma in situ (0.4%) and Paget's disease (2.0%). ER positivity was 48.9% and PR 46.9%. ER positive patients showed survival benefit compared to ER negative patients. The common sites of distant metastases were lung, bone and liver. CONCLUSIONS: Our patients with breast cancer were younger than those of western and showed the impacts on survival according to the lymph node status,tumor size.
