New finding of the expression of human beta defensin-4 in healthy gingiva.

Author: Xinyi LI ¹ ; Dingyu DUAN ; Panpan WANG ; Bo HAN ; Yi XU
Author Information

1. State Key Laboratory of Oral Diseases, Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Gingiva; Humans; RNA, Messenger; beta-Defensins
From: West China Journal of Stomatology 2013;31(2):165-168
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression and the distribution of human beta defensin (hBD)-4 in healthy gingiva.
METHODSHealthy gingival specimens were collected. The expression of hBD-4 peptides in 18 gingival specimens were detected by immunohistochemistry. The hBD-4 mRNA were determined in freshly isolated gingival tissue by real time reverse transcription-polymerase chain reaction (real time RT-PCR) in 30 gingival specimens.
RESULTSIn 18 gingival specimens, hBD-4 peptides were expressed in 13 gingival specimens. In 30 gingival specimens, hBD-4 were detected in 4 gingival specimens by real time RT-PCR.
CONCLUSIONThe distribution and the expression levels of hBD-4 are different in healthy gingiva. This result may suggest that the hBD-4 play a role in maintaining the periodontal health.