Hepatitis B virus core protein as an epitope vaccine carrier: a review.
- Author:
Ying YIN
1
;
Junjie XU
;
Wei CHEN
Author Information
1. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China.
- Publication Type:Journal Article
- MeSH:
Adjuvants, Immunologic;
pharmacology;
Drug Carriers;
Epitopes;
genetics;
immunology;
Genetic Vectors;
Hepatitis B Core Antigens;
genetics;
immunology;
Humans;
Recombinant Fusion Proteins;
genetics;
immunology;
metabolism;
Vaccines, Synthetic;
biosynthesis;
immunology
- From:
Chinese Journal of Biotechnology
2010;26(4):431-438
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus core (HBc) proteins have been used as carrier for foreign epitopes since the 1980s. They could self-assemble into icosahedral particles. Foreign epitopes could be inserted into HBc protein in various protein regions, including the N- or C-terminal and the major immunodominant region (MIR). The factors relevant in the design of HBc particles for vaccine purpose are summarized in this review.
