An analysis of the characteristics and etiology of hand, foot and mouth disease in a Guangzhou sentinel hospital from May to December, 2008.
- Author:
Lu-lu GAO
1
;
Qing CHEN
;
Xiao-zhu ZHONG
;
Xi-lan TAN
;
Jie ZHOU
;
Jiang GUO
;
Shou-yi YU
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; China; epidemiology; Enterovirus A, Human; isolation & purification; Female; Hand, Foot and Mouth Disease; epidemiology; virology; Humans; Incidence; Male; Reverse Transcriptase Polymerase Chain Reaction
- From: Journal of Southern Medical University 2010;30(6):1333-1335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the characteristics and etiology of hand, foot and mouth disease (HFMD) in a sentinel hospital of Guangzhou.
METHODSThe epidemiological data and clinical specimens were collected from May to December, 2008 for virological investigations (viral isolation, RT-PCR and molecular identification) and phylogenetic analysis.
RESULTSA total of 309 clinical cases were reported, and the incidence was the highest in 2-4-year-old children, among whom only 15 developed complications, with human enterovirus 71 (HEV71) as the main pathogen (64.7%). Phylogenetic analysis indicated that ten Guangzhou EV71 isolates belonged to Cluster C4a.
CONCLUSIONHFMD is an important infectious disease in children resulting from infections by HEV71 as the main pathogen in 2008, and the Guangzhou C4a strains co-evolved with the isolates from other provinces in China and the neighboring countries.
