Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer.
- Author:
Young Seob SHIN
1
;
Yong Sik YOON
;
Seok Byung LIM
;
Chang Sik YU
;
Tae Won KIM
;
Heung Moon CHANG
;
Jin Hong PARK
;
Seung Do AHN
;
Sang Wook LEE
;
Eun Kyung CHOI
;
Jin Cheon KIM
;
Jong Hoon KIM
Author Information
- Publication Type:Original Article
- Keywords: Radiotherapy; Rectal neoplasms; Neoadjuvant therapy; Transanal endoscopic microsugery
- MeSH: Chemoradiotherapy*; Fistula; Follow-Up Studies; Humans; Minimally Invasive Surgical Procedures; Neoadjuvant Therapy; Polymerase Chain Reaction; Radiotherapy; Rectal Neoplasms*; Recurrence; Retrospective Studies
- From:Radiation Oncology Journal 2016;34(3):177-185
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. MATERIALS AND METHODS: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients’ characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months. RESULTS: All patients received transanal excision or transanal minimally invasive surgery. Of 34 patients, 19 patients (55.9%) presented pathologic complete response (pCR). The 3-year local recurrence-free survival and disease free-survival were 100.0% and 97.1%, respectively. There was no recurrence among the patients with pCR. Except for 1 case of grade 4 enterovesical fistula, all other late complications were mild and self-limiting. CONCLUSION: PCRT followed by an LE might be feasible as an alternative to total mesorectal excision in good responders with clinical T2N0 distal rectal cancer.
