Effect of the ethanol extract of Picrorhiza scrophulariiflora on the progression of chronic kidney disease in a rat remnant kidney model.
- Author:
Jian-xun FENG
1
;
Hong-Yan LI
;
Zhi-qiang LIU
;
Zhan-mei ZHOU
;
Jian-wei TIAN
;
Min LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Progression; Drugs, Chinese Herbal; pharmacology; therapeutic use; Male; Nephrectomy; Oxidative Stress; drug effects; Phytotherapy; Picrorhiza; chemistry; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; drug therapy; pathology
- From: Journal of Southern Medical University 2010;30(7):1505-1508
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of the ethanol extract of Picrorhiza scrophulariiflora (EPS) on renal function and tissue damage in a rat remnant kidney model.
METHODSRat models of chronic kidney disease induced by 5/6 nephrectomy (5/6 Nx) were randomly assigned into two groups for treatment with a gavage of either EPS or vehicle for 9 weeks. The rats in the control group received only sham operation.
RESULTSCompared with vehicle-treated 5/6 Nx rats, the EPS-treated rats displayed significantly decreased urinary excretion of malondialdehyde, serum levels of AGEs and AOPPs, and increased serum SeGSHPx activities. These changes were associated with attenuated urinary protein excretion, glomerular sclerosis and interstitial fibrosis.
CONCLUSIONEPS can obviously improve the renal functions and renal pathologies in rats with chronic kidney disease probably by inhibiting the oxidative stress.
