Predictive value of fluorescence in situ hybridization in patients with bladder cancer.
- Author:
Zheng-fei SHAN
1
;
Shao-bin ZHENG
;
Peng WU
;
Wan-long TAN
;
Yi ZUO
;
Hai-kuan ZHOU
;
Huan QI
;
Peng ZHANG
;
Hong-mei PENG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; diagnosis; Cytodiagnosis; Female; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Sensitivity and Specificity; Urinary Bladder Neoplasms; diagnosis; Urine; cytology; Young Adult
- From: Journal of Southern Medical University 2010;30(7):1597-1603
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the value of fluorescence in situ hybridization (FISH) in the diagnosis of bladder cancer.
METHODSUrine samples from 100 patients suspected of having bladder cancer were collected before cystoscopy for immediate urine cytology and FISH analysis. The criteria for FISH abnormality were determined by evaluating the urine specimens from 20 subjects without urogenital neoplasm.
RESULTSThe overall sensitivity of cytology and FISH was 43.2% and 82.4%, and their specificity was 92.3% and 88.5%, with diagnostic concordance rate of 56.0% and 84.0%, respectively. The differences between FISH and cytology showed statistical significance in the sensitivity, diagnostic concordance rate, non-muscle-invasive cancer and primary cancer.
CONCLUSIONThe sensitivity and efficiency of FISH in the detection of bladder cancer are superior to those of cytology, especially for prophase cancer.
