Differences in serum and ascites cytokine production caused by Gram-positive or -negative bacterial infection in patients with multiple organ dysfunction syndrome.
- Author:
Rong QU
1
;
Si-min YANG
;
Wei-qun DAI
;
Chu-yang YE
;
Yan JI
Author Information
- Publication Type:Journal Article
- MeSH: Ascites; metabolism; Gram-Negative Bacterial Infections; blood; metabolism; Gram-Positive Bacterial Infections; blood; metabolism; Humans; Interleukin-10; blood; metabolism; Interleukin-6; blood; metabolism; Interleukin-8; blood; metabolism; Multiple Organ Failure; blood; metabolism; microbiology; Serum; metabolism; Tumor Necrosis Factor-alpha; blood; metabolism
- From: Journal of Southern Medical University 2010;30(7):1626-1627
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the differences in the cytokine levels in the serum and ascites caused by Gram-positive or Gram-negative bacterial infection in patients with multiple organ dysfunction syndrome (MODS).
METHODSThe cytokines in the serum and ascites of the patients were examined by enzyme-linked immunosorbent assay in 27 patients with MODS due to Gram-positive (n=13) or Gram-negative (n=14) bacterial infection at day 1.
RESULTSThe levels of LPS and TNF-a were higher in the patients with Gram-negative bacterial infection than in patients with Gram-positive infection (P<0.05), but the levels of IL-6, IL-8 and IL-10 remained comparable between the two groups (P>0.05).
CONCLUSIONTesting of LPS and TNF-a in the serum and ascites of patients with MODS caused by Gram-positive or -negative bacterial infection may help to identify the pathogens for peritonitis resulting in MODS.
