Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis.
- Author:
Fan CHEN
1
;
Wen CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Coronary Disease; genetics; Gene Frequency; Genotype; Humans; Interleukin 1 Receptor Antagonist Protein; genetics; Interleukin-1beta; genetics; Minisatellite Repeats; Polymorphism, Genetic; Risk Factors
- From: Journal of Southern Medical University 2010;30(7):1635-1638
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the correlation between the gene polymorphism of IL-1beta-511 or IL-1RN VNTR and the risk of coronary heart disease (CHD).
METHODSThe patient-control studies on the association of IL-1=-511 or IL-1RN VNTR gene polymorphism with the risk of CHD were searched according to the inclusion criteria. Heterogeneity tests were conducted for the data from each study before Meta-analysis.
RESULTSFor the 7 studies addressing the correlation between IL-1beta-511 polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.04 with 95% CI of 0.93-1.18 (Z=0.71, P=0.48). For the 5 studies of the correlation between IL-1RN VNTR polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.01 and the 95% CI was 0.78-1.17 (Z=0.08, P=0.93).
CONCLUSIONThe gene polymorphism of IL-1beta-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype.
