Therapeutic effects of amiodarone and metoprolol on chronic heart failure complicated by ventricular arrhythmia.
- Author:
Hong-Song LÜ
1
;
Bin-Bin HE
;
Gui-Hua HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adrenergic beta-Antagonists; therapeutic use; Adult; Amiodarone; therapeutic use; Anti-Arrhythmia Agents; therapeutic use; Chronic Disease; Drug Therapy, Combination; Female; Heart Failure; complications; drug therapy; physiopathology; Humans; Male; Metoprolol; therapeutic use; Tachycardia, Ventricular; drug therapy; etiology; physiopathology; Treatment Outcome; Ventricular Premature Complexes; drug therapy; etiology
- From: Journal of Southern Medical University 2009;29(6):1240-1242
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the therapeutic effects of amiodarone and metoprolol, either alone or in combination, on chronic heart failure (CHF) complicated by ventricular arrhythmia.
METHODSA total of 110 NYHA class II-III patients with CHF complicated by ventricular arrhythmia were randomly divided into amiodarone group, metoprolol group and amiodarone + metoprolol group. The therapeutic effects was evaluated at the end of the 1-year follow-up.
RESULTSAmiodarone, metoprolol and their combination produced statistically different therapeutic effects (P<0.05). Compared with amiodarone and metoprolol used alone, amiodarone combined with metoprolol resulted in significant cardiac function improvement (P<0.05) and ventricular arrhythmia control (P<0.01). During the 1-year follow-up, the readmission rate and cardiac event rate in the amiodarone + metoprolol group were significantly lower than those in amiodarone group (P<0.01) and metoprolol group (P<0.05). The adverse reaction rates in the 3 groups were similar (P>0.05).
CONCLUSIONThe combination of amiodarone and metoprolol produces better effect than amiodarone or metoprolol alone in the treatment of CHF complicated by ventricular arrhythmia.
