Effect of Helicobacter pylori eradication on childhood acute idiopathic thrombocytopenic purpura.
- Author:
Chao-Xia LI
1
;
Di-Jun LIU
;
Chun-Qiu PAN
;
Xian-Fu SANG
;
Xu LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Anti-Bacterial Agents; therapeutic use; Child; Child, Preschool; Drug Therapy, Combination; Female; Helicobacter Infections; drug therapy; Helicobacter pylori; drug effects; immunology; Humans; Male; Prednisone; therapeutic use; Purpura, Thrombocytopenic, Idiopathic; immunology; microbiology
- From: Journal of Southern Medical University 2009;29(6):1243-1244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of Helicobacter pylor (Hp) eradication in children with acute idiopathic thrombocytopenic purpura (ITP).
METHODSNinety-three children with acute ITP and Hp infection were divided into two groups and treated with prednisone and Hp eradication (group A, 51 cases) or with prednisone without Hp eradication (group B, 42 cases).
RESULTSThe Hp eradication rate was 94.1% in group A. No difference was found in the therapeutic effects on IPT between the two groups, but the recurrence rate in one year in group A was significantly lower than that in group B.
CONCLUSIONNHp eradication does not obviously enhance the therapeutic effect on childhood acute ITP, but can decrease the relapse rate in one year. HP eradication therapy is recommended in children with acute ITP and Hp infection.
