Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment.
- Author:
Lan GAO
1
;
Yan-hui LIU
;
Li-fen LI
;
Ya-min WU
;
Ming-bo WANG
;
Jing SHI
;
Bing YUAN
;
Juan SONG
;
Yong-ming HE
;
Dai-kui WEI
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Spontaneous; blood; genetics; Adult; Antiviral Agents; therapeutic use; Centromere; genetics; Chromosome Aberrations; Cytomegalovirus Infections; blood; drug therapy; genetics; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; blood; drug therapy; genetics; Young Adult
- From: Journal of Southern Medical University 2009;29(9):1846-1847
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of peripheral blood chromosomal centromere aberration in patents with cytomegalovirus (CMV) infection after anti-viral treatment.
METHODSSixty-two patients with early spontaneous abortion and CMV infection analyzed for their peripheral blood chromosomal centromere using simultaneous silver staining before and after anti-viral treatment.
RESULTSThe patients with CMV infection had high rate of centromere aberration, which was decreased significantly after anti-viral treatment (P<0.0001).
CONCLUSIONCMV infection is a risk factor for peripheral blood chromosomal centrimere aberration. Anti-viral treatment can decrease the rate of centrimere aberration aberration. Detection of peripheral blood chromosomal centrimere aberration allows the assessment of the severity of infection and the condition after treatment.
