Antineoplastic effect of koumine in mice bearing H22 solid tumor.
- Author:
Jing CAI
1
;
Lin-sheng LEI
;
De-biao CHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; therapeutic use; Female; Gelsemium; chemistry; Indole Alkaloids; isolation & purification; therapeutic use; Liver Neoplasms, Experimental; drug therapy; immunology; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phytotherapy
- From: Journal of Southern Medical University 2009;29(9):1851-1852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.
METHODSThe changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.
RESULTSKoumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.
CONCLUSIONKoumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.
