Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic rabbits.
- Author:
Hong-yan CAO
1
;
Ling QIN
;
Ke-xin HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Atherosclerosis; metabolism; Drugs, Chinese Herbal; pharmacology; Male; Matrix Metalloproteinase 3; genetics; metabolism; Matrix Metalloproteinase 9; genetics; metabolism; PPAR gamma; genetics; metabolism; Rabbits; Random Allocation
- From: Journal of Southern Medical University 2009;29(9):1887-1889
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Tongxinluo on the expressions of matrix metalloproteinase-3 (MMP-3), MMP-9 and peroxisome proliferators-activated receptor gamma (PPARgamma) in atherosclerotic rabbits and explore the mechanism of its anti-atherosclerotic effect.
METHODSTwenty-four rabbits were randomized equally into control group, atherosclerotic model group (fed with high-fat diet for 14 weeks) and Tongxinluo group. The expressions of MMP-3, 9 and PPARgamma in the 3 groups were observed by means of immunohistochemistry.
RESULTSThe expressions of MMP-3, 9 and PPARgamma in the model group and Tongxinluo group were significantly higher than those in the control group (P<0.01). After high-fat diet feeding for 14 weeks, Tongxinluo group showed significantly lower expressions of MMP-3 and 9 but higher expression of PPARgamma than the model group (P<0.01).
CONCLUSIONTongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma, which might be the mechanism of its anti-atherosclerotic effect.
