Transcatheter arterial chemoembolization with high-dose iodized oil for hepatic VX2 tumor in rabbits.
- Author:
Liang-shan LÜ
1
;
Qing-yong MA
;
Ya-min LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Catheterization, Peripheral; Chemoembolization, Therapeutic; methods; Contrast Media; administration & dosage; Dose-Response Relationship, Drug; Drug Carriers; administration & dosage; Female; Hepatic Artery; Iodized Oil; administration & dosage; Liver Neoplasms, Experimental; therapy; Male; Rabbits
- From: Journal of Southern Medical University 2009;29(10):2084-2087
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of transcatheter arterial chemoembolization (TACE) with high-dose iodized oil on hepatic tumor growth and metastasis in rabbits.
METHODSForty-eight rabbits with implanted VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high-dose iodized oil TACE group to receive perfusion through the hepatic artery with 0.9% saline, 5 mg adriamycin with routine-dose iodized oil, and 5 mg adriamycin with high-dose iodized oil, respectively. The tumor volume, tumor necrosis, intrahepatic and lung metastasis were examined 2 weeks after TACE.
RESULTSNo significant difference was found in the tumor volume between the 3 groups before TACE (P>0.05). The rabbits receiving TACE with iodized oil, especially at the high dose, showed significantly reduced tumor volume as compared with the control group (P<0.01). TACE with high-dose iodized oil resulted in significantly increased tumor necrosis rate in comparison with the control group and TACE with a routine dose of iodized oil (P<0.05); high-dose iodized oil TACE was also associated with reduced intrahepatic and lung metastasis as compared routine dose iodized oil TACE (P<0.05).
CONCLUSIONTACE with high-dose iodized oil can obviously inhibit the growth and intrahepatic and lung metastasis of transplanted VX2 liver tumor in rabbits .
