Diagnostic Efficacy of Exercise Tc - 99m Tetrofosmin SPECT in Patients with Coronary Artery Disease.
- Author:
Ji Yong CHOI
1
;
Jin Yong HWANG
;
Jong Hyeon HWANG
;
Hyeon Ju LIM
;
Hun Sik PARK
;
Yong Keun CHO
;
Shung Chull CHAE
;
Jae Eun JUN
;
Wee Hyun PARK
;
Byeong Cheol AHN
;
Jae Tae LEE
;
Kyu Bo LEE
Author Information
1. Department of Internal Medicine, Cotholic University of Taegu-Hyosung, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Tc - 99m tetrofosmin;
SPECT;
Coronary artery disease
- MeSH:
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Diagnosis;
Humans;
Myocardial Perfusion Imaging;
Myocardium;
Phenobarbital;
Sensitivity and Specificity;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Medicine
1997;53(6):759-768
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Tetrofosmin is a new Tc-99m labeled myocardial perfusion imaging agent that shows slow clearance from the myocardium and rapid clearance from background organs. The purpose of this study was to assess the ability of exercise Tc-99m tetrofosmin single photon emission computed tomography(SPECT) to identify and localize coronary artery disease. METHODS: The study population consists of 49 patients with suspected coronary artery disease who underwent both exercise Tc-99m tetrofosmin SPECT and coronary angiography within 2 weeks. Using the one day imaging protocol, 7-10mCi of Tc-99m tetrofosmin was injected at rest and 4 hours later, 25 mCi of Tc-99m tetrofosmin was injected at peak exercise. RESULTS: The sensitivity and specificity of exercise Tc-99m tetrofosmin SPECT was 94.9% and 60% for detection of coronary artery disease with luminal narrowing more than 50%, and 96.4% and 33.3% for detection of coronary artery disease with luminal narrowing more than 70%. The sensitivity of exercise Tc-99m tetrofosmin SPECT for detection of individual stenosed vessels(>or=50% and >or=70% coronary stenosis) was 79.2%, 100% for LAD, 55.6%, 55.6% for LCx and 85.0%, 92.9% for RCA and the specificity was 88.0%, 75.0% for LAD, 100%, 87.5% for LCx, 86.2%, 77.1% for RCA respectively. CONCLUSION: Exercise Tc-99m tetrofosmin SPECT appears to be an feasible and useful noninvasive test for the diagnosis of coronary artery disease
