Neuroprotective role of silent information regulator 1 in Alzheimer's disease.
- Author:
Xiao-Rong YANG
1
;
Rui WANG
;
Hua-Ping QIN
;
Xin ZHAO
;
Nai-Hong LIU
;
Ce ZHANG
Author Information
1. Department of Physiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan 030001, China.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
genetics;
physiopathology;
Animals;
Energy Metabolism;
physiology;
Humans;
Neuroprotective Agents;
Sirtuin 1;
physiology;
Transcription, Genetic;
physiology
- From:
Acta Physiologica Sinica
2011;63(4):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator 1 (SIRT1), an NAD(+)-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer's disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.
