Function and biological activities of the autotaxin-LPA axis.
- Author:
Zong-Wei LI
1
;
Ya-Rui ZHAO
;
Chao ZHAO
;
Rong FU
;
Zhuo-Yu LI
Author Information
1. Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Movement;
physiology;
Cell Proliferation;
Humans;
Lysophosphatidylcholines;
metabolism;
Lysophospholipids;
metabolism;
physiology;
Phospholipases;
metabolism;
Phosphoric Diester Hydrolases;
metabolism;
physiology;
Receptors, G-Protein-Coupled;
physiology
- From:
Acta Physiologica Sinica
2011;63(6):601-610
- CountryChina
- Language:Chinese
-
Abstract:
Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
