Cell adhesion molecules in human embryo implantation.
- Author:
Michiko N FUKUDA
1
;
Kazuhiro SUGIHARA
Author Information
1. Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA. michiko@burnham.org
- Publication Type:Journal Article
- MeSH:
Cadherins;
physiology;
Cell Adhesion Molecules;
physiology;
Embryo Implantation;
Epithelial Cells;
metabolism;
Humans;
Integrins;
physiology;
L-Selectin;
physiology;
Signal Transduction
- From:
Acta Physiologica Sinica
2012;64(3):247-258
- CountryChina
- Language:English
-
Abstract:
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.
