Research on anticancer activity of isocorydine and its derivatives.
10.19540/j.cnki.cjcmm.20170512.008
- Author:
Qian YAN
1
;
Ru-Xia LI
1
;
Ai-Yi XIN
1
;
Jun-Xi LIU
1
;
Wen-Guang LI
2
;
Duo-Long DI
1
Author Information
1. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Insititute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China.
2. School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
SAR;
anticancer activity;
aporphine alkaloids;
isocorydine
- From:
China Journal of Chinese Materia Medica
2017;42(16):3152-3158
- CountryChina
- Language:Chinese
-
Abstract:
Isocorydine and its analogs were extracted from Dicranostigma leptopodum and Stephania yunnanensis through the method of natural products chemistry. Its derivatives were prepared by chemical structure modifications from isocorydine. MTT method was used to study the inhibitory effect of those compounds on the growth of HepG2, HeLa and MGC-803 cancer cell lines in vitro. The results showed that isocorydine and its analogs all have the growth inhibition for those cancer cell lines. This paper investigated the structure-activity relationship of isocorydine and its derivatives with anticancer activity in the aspect of stereochemical structure, functional groups positions of the compounds and the electron density of aromatic rings based on the single crystal diffraction structure and the molecular docking of EGFR and isocorydine.
