Adverse reaction and screening of sensitizing substance of Shuxuening injection.
10.19540/j.cnki.cjcmm.2017.0129
- Author:
Yan YI
1
;
Chun-Ying LI
1
;
Yu-Shi ZHANG
1
;
Yong ZHAO
1
;
Lian-Mei WANG
1
;
Chen PAN
1
;
Su-Yan LIU
1
;
Jing-Zhuo TIAN
1
;
Jia-Yin HAN
1
;
Ai-Hua LIANG
1
Author Information
1. Key Laboratory of Beijing for Identification and Safety of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Shuxuening injection;
allergic reactions;
pseudoallergenic substances;
pseudoallergic reactions
- From:
China Journal of Chinese Materia Medica
2017;42(16):3198-3205
- CountryChina
- Language:Chinese
-
Abstract:
In this study, by the means of the active systemic allergy test in guinea pigs, passive skin allergy test in rats and pseudoallergic test in mice, it was determined that the "allergic reaction" of Shuxuening injection(SXNI) may not be a true IgE-mediated allergic reactions, but mainly of pseudoallergic reaction. Further pseudoallergic test proved that the pseudoallergic reactions of SXNI had difference between batches and showed dose dependence, so it was recommended to establish SXNI pseudoallergic reaction detection method for timely detecting and controlling the product risk of each batch products. In addition, as the pseudoallergic reactions of SXNI were dose-dependent, the dose and concentration of SXNI should be strictly controlled in clinical use. Then the main pseudoallergenic reaction test was conducted for the main monomer components in SXNI and the different fractions of Ginkgo biloba extract in mice, and the results showed that the sensitizing substances may mainly exist in YXY-3 fractions containing flavonol glycosides. By further chemically separating YXY-3, we got four chemical components. Among these four components, YXY-3-1 and YXY-3-2 were testified as the main allergenic components in SXNI through pseudoallergic test in mice. To make sure the specific chemical constituent that is responsible for the pseudoallergic reaction, in-depth study in follow-up experiments should be needed.
