Evaluate effects of different drying methods on quality of Tianshu capsule on substance basis.
10.19540/j.cnki.cjcmm.20170719.005
- Author:
Meng-Ting ZHANG
1
;
Yu-An BI
2
;
Xin ZHANG
2
;
Gui-Hong XU
2
;
Wen-Zhe HUANG
2
;
Zhen-Zhong WANG
2
;
Wei XIAO
1
Author Information
1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China.
- Publication Type:Journal Article
- Keywords:
Tianshu capsule;
UPLC-ESI-MS/MS;
chemical components;
fingerprint;
hot air circulation drying;
spray drying
- From:
China Journal of Chinese Materia Medica
2017;42(18):3537-3545
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of hot air circulation drying and spray drying on the quality of Tianshu capsule from the view point of chemical compositions. UPLC-DAD was used to establish the fingerprint of Tianshu capsules for the first time, and the main chemical constituents were identified by UPLC-Q-TOF-MS/MS. A total of 62 compounds were identified in this method, 21 of which were reported in Tianshu capsules for the first time. The results showed that there were no significant differences in the identification of the chemical constituents types between these two methods, but the contents of some constituents were different. The common patterns generated by the 10 batches of hot air cycle drying samples were used as the control fingerprint, and the similarity of the spray drying samples fingerprints was 0.877, with high similarity of the fingerprints between these two methods. UPLC-DAD combined with UPLC-Q-TOF-MS/MS technology was used for the first time to evaluate the chemical constituents of Tianshu capsule rapidly, comprehensively and accurately, providing technical support for the quality evaluation of Tianshu capsule.
