Preparation and evaluation of dioscin nanostructured lipid carriers.
10.19540/j.cnki.cjcmm.20170808.001
- Author:
Ying JIAO
1
;
Hong-Ye JU
1
;
Kun-Xia HU
1
;
Zhi-Shu TANG
1
;
Xiao SONG
1
Author Information
1. School of pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
- Publication Type:Journal Article
- Keywords:
appraise;
dioscin;
nanostructured lipid carrier;
preparation and construction
- From:
China Journal of Chinese Materia Medica
2017;42(19):3747-3754
- CountryChina
- Language:Chinese
-
Abstract:
In this report, a heat and high-pressure homogenization method was used to prepare dioscin nanostructured lipid carriers, and the formulation of dioscin nanostructured lipid carriers was optimized by central composite design-response surface methodology. In vitro evaluation data showed that the preparation of dioscin nanostructured lipid carriers under optimal process by central composite design-response surface methodology had a spherical shape and homogeneous size distribution, with a particle size of (90.9±0.6) nm, a polydispersity index of (0.253±0.07), Zeta potential of (-45.7±0.5) mV, encapsulation efficiency of (90.2±0.5)%, and the drug loading of (23.30±0.10)%. These results clearly indicate that the preparation of dioscin nanostructured lipid carriers made with the heat and high-pressure homogenization method have very good physical and chemical properties, suitable for therapeutic applications.
