Research progress of pharmacokinetics and pharmacodynamics of total glucosides of peony in hepatoprotective effects.
10.19540/j.cnki.cjcmm.2017.0153
- Author:
Zhi-Yan ZUO
1
;
Shu-Yu ZHAN
1
;
Xuan HUANG
1
;
Bao-Yue DING
1
;
Yu-Qian LIU
1
;
Yu-Er RUAN
1
;
Ning-Hua JIANG
2
Author Information
1. Medical College of Jiaxing University, Jiaxing 314001, China.
2. The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
- Publication Type:Journal Article
- Keywords:
hepatoprotective;
paeoniflorin;
pharmacodynamics;
pharmacokinetics;
total glucosides of peony
- From:
China Journal of Chinese Materia Medica
2017;42(20):3860-3865
- CountryChina
- Language:Chinese
-
Abstract:
Total glucosides of peony (TGP), containing the effective components of paeoniflorin (Pae), albiflorin (Alb) and so on, are effective parts of Radix Paeoniae Alba. And it possesses extensive pharmacological actions, one of which is hepatoprotective effect. In recent years, abundant of pharmacokinetics and pharmacodynamics research of TGP in hepatoprotective effects have been performed. However, the relative medicine of TGP in hepatoprotective effect has not been developed for clinical application. In order to provide reference for the development and rational clinical application of TGP, the research progresses of pharmacokinetics and pharmacodynamics of TGP in hepatoprotective effect were summarized in this paper. Pharmacokinetics research has clarified the process of absorption, distribution, metabolism and excretion of TGP in vivo, and liver injury disease can significantly influence its metabolic processes. Pharmacodynamics studies suggested that TGP can protect against acute liver injury, non-alcoholic fatty liver diseases (NAFLD), chronic liver fibrosis and liver cancer. However, the action mechanism and in vivo process about hepatoprotective effects of TGP have not been clearly revealed. How liver injury influences the metabolism of TGP and its integrated regulation through multiple targets need to be further studied. The combined pharmacokinetics and pharmacodynamics studies should be performed in favour of medicine development and clinical application of TGP in hepatoprotective effects.
