Sesquiterpenes with anti-metastasis breast cancer activity from Chloranthus henryi.
10.19540/j.cnki.cjcmm.2017.0159
- Author:
Shan-Shan ZHANG
1
;
Jian-Jiang FU
1
;
Huai-Yuan CHEN
1
;
Lin-Feng TU
1
;
Chun-Rong XIAO
1
;
Rui-Zeng ZHANG
1
;
Ding-Ping LIU
1
;
Yong-Ming LUO
1
Author Information
1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Chloranthus henryi;
anti-metastasis breast cancer activity;
sesquiterpenes
- From:
China Journal of Chinese Materia Medica
2017;42(20):3938-3944
- CountryChina
- Language:Chinese
-
Abstract:
To study sesquiterpenes with anti-metastasis breast cancer activity from Chloranthus henryi, ten sesquiterpenes ,zedoarofuran (1), chlorajapolide D (2), 4β, 8β-dihydroxy-5α(H)-eudesm-7(11)-en-8, 12-olide (3), curcolonol (4), lasianthuslactone A (5), chlomultin C (6), (1E,4Z)-8-hydroxy-6-oxogermacra-1(10), 4, 7(11) -trieno-12, 8-lactone (7), shizukanolide E (8) , shizukanolide F (9) , 9α-hydroxycurcolonol (10), and five bis-sesquiterpenes, shizukaol B (11), shizukaol C (12) , cycloshizukaol A (13) , sarcandrolide B (14) , henriol A(15), were isolated by using different kinds of column chromatography methods from the ethyl acetate part of Ch.henryi and their structures were identified based on spectroscopic methods. Compounds 2, 8, 9, and 10 were obtained from the genus Chloranthus for the first time. Compounds 2, 5, 8-10, 12,and 14 were obtained from this plant for the first time. Some isolated compounds were subjected to evaluate the anti-metastasis breast cancer activity by using pharmacological methods, and only compounds 4, 11, and 12 were potent active.