Chemical constituents from stems of Ilex asprella.
10.19540/j.cnki.cjcmm.20170905.003
- Author:
Bing-Zhao DU
1
;
He-Xin-Ge ZHANG
1
;
Xin-Yao YANG
1
;
Rui-Fei ZHANG
1
;
Xu YIN
1
;
Jian-Yong XING
2
;
Zheng-Zhou HAN
2
;
Zeng-Ping GAO
1
;
Xing-Yun CHAI
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
2. Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518029, China.
- Publication Type:Journal Article
- Keywords:
Aquifoliaceae;
Ilex;
Ilex asprella;
anti-inflammatory activity;
chemical constituents
- From:
China Journal of Chinese Materia Medica
2017;42(21):4154-4158
- CountryChina
- Language:Chinese
-
Abstract:
Phytochemical investigation on the stems of Ilex asprella by using various chromatographic techniques led to the isolation of 13 compounds. By spectroscopic analyses and comparisons the spectral data with those in literatures, these compounds were identified as salicifoneoliganol(1), rel-(7R,8S)-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolignan-4,9,9'-triol 9-β-D-glucopyranoside(2),(+)-cycloolivil(3),(+)-syringaresinol-4'-O-β-D-monoglucoside(4), liriodendrin(5), caffeic acid (6), 3,4-dihydroxy-5-methoxybenzaldehyde(7), benzene-1,2,4-triol(8), 3,4,5-trimethoxyphenyl-1-O-β-D-apiofuranosyl(1″→6')-glucopyranoside(9), aeculetin(10), cryptochlorogenic acid ethyl ester(11), chlorogenic acid ethyl ester(12), and rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo [3,2,1]oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(13). Among them, compounds 7, 8, 11, and 13 were isolated from genus Ilex for the first time, and 1-3, 9, 10, and 12 were isolated from this speciesfor the first time. The anti-inflammatory assay results of these compounds showed that compounds 1 and 9 showed moderate inhibitory effect against NO production in RAW 267. 4 cells with IC₅₀ values of 35.7 and 50.6 μmol•L⁻¹, in vitro respectively, whereas compound 10 showed weak inhibition(IC₅₀ value 98.7 μmol•L⁻¹).
