Epithelial Sodium and Chloride Channels and Asthma.

Wen Wang; Hong-long JI

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Epithelial Sodium and Chloride Channels and Asthma.

Author: Wen WANG ^{1
,

2} ; Hong-Long JI
Author Information

1. Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing 100020, China
2. Department of Cellular and Molecular Biology, Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler Texas 75708, USA, .
Publication Type:Journal Article
MeSH: Asthma; physiopathology; Chloride Channels; physiology; Cystic Fibrosis; genetics; Cystic Fibrosis Transmembrane Conductance Regulator; genetics; Epithelium; physiopathology; Humans; Respiratory System; physiopathology; Sodium Channels; physiology
From: Chinese Medical Journal 2015;128(16):2242-2249
CountryChina
Language:English
Abstract:
OBJECTIVETo focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel.
DATA SOURCESThe data analyzed in this review were the English articles from 1980 to 2015 from journal databases, primarily PubMed and Google Scholar. The terms used in the literature search were: (1) ENaCs; cystic fibrosis (CF) transmembrane conductance regulator (CFTR); asthma/asthmatic, (2) ENaC/sodium salt; CF; asthma/asthmatic, (3) CFTR/chlorine ion channels; asthma/asthmatic, (4) ENaC/sodium channel/scnn1a/scnn1b/scnn1g/scnn1d/amiloride-sensitive/amiloride-inhibtable sodium channels/sodium salt; asthma/asthmatic, lung/pulmonary/respiratory/tracheal/alveolar, and (5) CFTR; CF; asthma/asthmatic (ti).
STUDY SELECTIONThese studies included randomized controlled trials or studies covering asthma pathogenesis and clinical manifestations related to ENaC/chlorine ion channels within the last 25 years (from 1990 to 2015). The data involving chronic obstructive pulmonary disease and CF obtained from individual studies were also reviewed by the authors.
RESULTSAirway surface liquid dehydration can cause airway inflammation and obstruction. ENaC and CFTR are closely related to the airway mucociliary clearance. Ion transporters may play a critical role in pathogenesis of asthmatic exacerbations.
CONCLUSIONSIon channels have been the center of many studies aiming to understand asthmatic pathophysiological mechanisms or to identify therapeutic targets for better control of the disease.