Some qualitative and quantitative dosage methods of artesunate by alcalimetry
- Author:
Hau Duc Tran
- Publication Type:Journal Article
- Keywords:
artesunate
- MeSH:
Artesunate;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
1999;282(10):9-11
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
On basis of the chemical structure of artesunate, 4 identification tests were proposed. They were as follows: Artesunate reacts with a potassium iodide solution to form iodine; artesunate reacts with 5% potassium dichromate solution and 2% sulphuric acid to form acid perchromic; artesunate reacts with cupri-tar-taric solution R to form a red precipitate; artesunat reacts with silver nitrate solution R and dilute ammonia R1 to form a silver mirror. A new method for the determination of artesunate was proposed as alkalimetric titration. The validation of the method was carried out and the results showed that the method was precise, linear, accurate and more specific than the current method.
