Helicobacter pylori in Human Stomach: Can It Be Called Mutualism or a Disease?.
10.4166/kjg.2012.59.5.329
- Author:
Dae Young CHEUNG
1
;
Tae Ho KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea. kimtaeho@catholic.ac.kr
- Publication Type:Review ; English Abstract
- Keywords:
Helicobacter pylori;
Immunity;
Tolerance;
Symbiosis
- MeSH:
Adaptive Immunity;
Epithelial Cells/metabolism/microbiology/pathology;
Helicobacter Infections/immunology/metabolism/*pathology;
Helicobacter pylori/*immunology;
*Host-Pathogen Interactions;
Humans;
Symbiosis;
T-Lymphocytes/immunology/metabolism
- From:The Korean Journal of Gastroenterology
2012;59(5):329-337
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Helicobacter pylori (H. pylori) has been a major concern as a gastric pathogen with unique features since discovered in the end of the 20th century. Recent data on comparative genome study have revealed that H. pylori has successfully survived with its host though over 58,000 years of evolution and migration from continent to continent. To maintain the symbiotic relationship with human, H. pylori has come up with ways to induce host tolerance as well as exert harmful injuries. Studies about H. pylori have accumulated the knowledge about how the cellular and molecular interactions are controlled and regulated to decide whether the symbiotic relationship is directed to diseases or peaceful mutualism. We reviewed recent literatures and research outcomes about the H. pylori and host interaction in molecular and cellular basis.
