Usefulness of 18F-fluoro-2-deoxyglucose Positron Emission Tomography in Evaluation of Gastric Cancer Stage.
10.4166/kjg.2012.59.5.347
- Author:
Na Ri YOON
1
;
Jae Myung PARK
;
Hee Sun JUNG
;
Yu Kyung CHO
;
In Seok LEE
;
Myung Gyu CHOI
;
In Sik CHUNG
;
Kyo Young SONG
;
Cho Hyun PARK
Author Information
1. Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea. parkjerry@catholic.ac.kr
- Publication Type:Original Article ; English Abstract ; Research Support, Non-U.S. Gov't
- Keywords:
Stomach neoplasms;
Fluorodeoxyglucose F18;
Positron-emission tomography;
Lymph nodes;
Neoplasm metastasis
- MeSH:
Aged;
Female;
Fluorodeoxyglucose F18/chemistry/*diagnostic use;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging;
Positron-Emission Tomography;
Predictive Value of Tests;
ROC Curve;
Radiopharmaceuticals/chemistry/*diagnostic use;
Retrospective Studies;
Stomach Neoplasms/*diagnosis/radionuclide imaging;
Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology
2012;59(5):347-353
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The usefulness of 18F-fluoro-2-deoxyglucose (FDG)-PET in detecting primary cancer, lymph node metastasis, and distant metastasis were studied in the gastric cancer patients. METHODS: The subjects were 392 gastric cancer patients who received FDG-PET and an abdominal CT test prior to surgery. The results of FDG-PET and CT were compared with the surgical and pathologic results. RESULTS: The primary site detection rate of FDG-PET was 74.4%, 50.3% in early gastric cancer and 92.0% in advanced gastric cancer. Detection rate was higher when tumors were larger than 3.5 cm, had deeper depth of invasion, and at a later stage (p<0.05, respectively). In multivariate analysis, tumor size, spread of tumor cells beyond the muscle layer (> or =T2), and lymph node metastasis were statistically significant factors in primary site detection rate. The sensitivity, specificity, and positive predictive value of FDG-PET to lymph node metastasis were 59.6%, 88.8%, and 81.1% respectively, sensitivity being lower compared to CT while specificity and positive predictive value were higher. Sensitivity, specificity, and positive predictive value to distant metastasis were, respectively, 66.7%, 99.2%, and 88.0%, similar to CT. In 21 of the 392 patients (5.4%), synchronous double primary cancers were detected. CONCLUSIONS: In gastric cancer, usefullness of FDG-PET is limited to the advanced stage. Diagnostic value of this test was not superior to CT. However, FDG-PET may be useful in detecting synchronous double primary cancers.
