Regular paracetamol in severe dengue: a lethal combination?
- Author:
Chin Seng GAN
1
;
Sze Yee CHONG
;
Lucy Chai See LUM
;
Way Seah LEE
Author Information
1. Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia.
- Publication Type:Case Reports
- MeSH:
Acetaminophen;
adverse effects;
therapeutic use;
Antipyretics;
adverse effects;
therapeutic use;
Blood Coagulation;
Female;
Hepatic Encephalopathy;
drug therapy;
Humans;
Infant;
Liver Failure, Acute;
chemically induced;
Severe Dengue;
drug therapy;
Treatment Outcome
- From:Singapore medical journal
2013;54(2):e35-7
- CountrySingapore
- Language:English
-
Abstract:
An eight-month-old female infant with severe dengue disease, who was repeatedly given therapeutic paracetamol for severe dengue, developed fulminant liver failure with encephalopathy, gastrointestinal haemorrhage and severe coagulopathy. She responded to supportive measures and N-acetylcysteine infusion. This case highlights the potential danger of administering repeated therapeutic doses of paracetamol in childhood severe dengue disease with hepatitis.
