Healing the mucosa in Crohn's disease: does it matter?
- Author:
Khoon Lin LING
1
;
Sai Wei CHUAH
;
San Choon KONG
Author Information
1. Department of Gastroenterology and Hepatology, Singapore General Hospital, Outram Road, Singapore. ling.khoon.lin@sgh.com.sg
- Publication Type:Journal Article
- MeSH:
Biological Products;
therapeutic use;
Crohn Disease;
physiopathology;
therapy;
Diagnostic Imaging;
Endoscopy;
Hospitalization;
Humans;
Inflammation;
Intestinal Mucosa;
pathology;
physiopathology;
Remission Induction;
Treatment Outcome;
Ulcer;
complications
- From:Singapore medical journal
2013;54(4):185-189
- CountrySingapore
- Language:English
-
Abstract:
Clinical remission has been the therapeutic goal of Crohn's disease treatment for many years. While it has helped to ameliorate the symptoms, this treatment strategy has not brought about significant changes in the need for abdominal surgery in the natural history of Crohn's disease. The advent of biological agents (biologics) has shown that it is possible to induce and maintain mucosal healing in a significant proportion of treated patients. Data is also emerging to show that this has translated to fewer instances of hospitalisation and surgery for these patients. This is a paradigm shift in the therapeutic goal of Crohn's disease treatment.
