L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid.
- Author:
Xiu-hong LIU
1
;
Ji-cai FAN
;
Yang LIU
;
Zhi-cai SHANG
Author Information
- Publication Type:Journal Article
- MeSH: Coumarins; chemical synthesis; Ionic Liquids; chemistry; Proline; chemistry
- From: Journal of Zhejiang University. Science. B 2008;9(12):990-995
- CountryChina
- Language:English
- Abstract: The effect of L-proline as a promoter on the condensation reaction of salicylaldehyde or its derivatives with ethyl acetoacetate in neutral ionic liquid [emim]BF4 was studied. All reactions were carried out under mild reaction conditions and achieved high yields. Moreover, the ionic liquid containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity. The results show that the L-proline-[emim]BF4 system has a potential in contribution to the development of environmentally friendly and inexpensive processes in organic syntheses.
