Association of serum lipid profile with distant metastasis in breast cancer patients.
- Author:
Ye-Liu LIU
1
;
Hai-Xin QIAN
;
Lei QIN
;
Xiao-Jun ZHOU
;
Bo ZHANG
;
Xin CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Body Mass Index; Breast Neoplasms; blood; pathology; Cholesterol; blood; Cholesterol, HDL; blood; Cholesterol, LDL; blood; Female; Humans; Lipids; blood; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Neoplasm Staging; Nutritional Status; Risk Factors; Serum Albumin; Triglycerides; blood
- From: Chinese Journal of Oncology 2012;34(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEIn order to investigate whether the presence of distant metastases is associated with serum lipid abnormalities.
METHODSThe fasting serum lipid profile and various clinicopathological data of 324 breast cancer patients with and without synchronous distant metastases were collected and analyzed. The serum lipid profile, including total cholesterol (TC), triglycerides (TG), low-density (LDL-C) and high-density lipoprotein cholesterol (HDL-C) was determined. The nutritional status, the serum albumin was measured and body mass index (BMI) was calculated. Univariate analysis and multiple logistic regression analysis were carried out to investigate the association of serum lipid profile with distant metastases.
RESULTSUnivariate analysis showed that the distant metastasis rate was significantly higher in the breast cancer patients with an higher level of serum TC, TG, LDL-C, and LDL-C/HDL-C ratio (P < 0.05). Multiple logistic regression analysis showed that higher serum levels of TC, LDL-C and LDL-C/HDL-C ratio were independent risk factors for distant metastasis in breast cancer (OR = 2.324, 2.648 and 4.862, respectively).
CONCLUSIONSHyperlipidemia is significantly associated with the distant metastasis in breast cancer patients. Monitoring of serum lipid profile may be helpful to predict the occurrence of distant metastasis in breast cancer patients.
