Efficacy and survival status of retuximab-NCE regimen treatment in patients with relapsed or refractory B cell non-Hodgkin's lymphoma.
- VernacularTitle:利妥昔单抗联合NCE方案治疗难治性B细胞淋巴瘤的临床疗效
- Author:
Yun HOU
1
;
Hua-qing WANG
;
Kai FU
;
Xian-ming LIU
;
Hui-lai ZHANG
;
Zheng-zi QIAN
;
Li-hua QIU
;
Wei LI
;
Shi-yong ZHOU
;
Lan-fang LI
;
Xi-shan HAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alopecia; chemically induced; Antibodies, Monoclonal, Murine-Derived; adverse effects; therapeutic use; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Cisplatin; administration & dosage; Disease-Free Survival; Drug Resistance, Neoplasm; Etoposide; administration & dosage; Fatigue; chemically induced; Female; Follow-Up Studies; Humans; Leukopenia; chemically induced; Lymphoma, B-Cell; drug therapy; pathology; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Remission Induction; Retrospective Studies; Rituximab; Survival Rate; Thrombocytopenia; chemically induced; Vinblastine; administration & dosage; analogs & derivatives; Young Adult
- From: Chinese Journal of Oncology 2012;34(4):306-310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study was to analyze the efficacy and toxicity of RNCE regimen in the treatment of relapsed or refractory B cell non-Hodgkin's lymphoma (NHL).
METHODSFrom January 2000 to December 2005, 46 patients with relapsed or refractory B cell NHL were treated by RNCE regimen with or without radiotherapy for the involved field. The clinical characteristics, response, toxicity and long-term survival results were analyzed retrospectively.
RESULTSA total of 46 patients were eligible. The complete response rate of second-line therapy was 52.17% (24/46), and the overall response rate was 82.61% (38/46). The median follow-up duration in this series was 69 months (range:6 to 102 months). The overall 1, 3, 5-year survival rate was 74.8%, 48.3%, 40.1%, respectively, with a median survival time of 30.2 months (5 to 65 months), and median progression free survival time of 10.9 months (2 to 31 months). The major toxicities were myelosuppression, GI toxicity, fatigue, fever and alopecia.
CONCLUSIONOur data show that RNCE regimen treatment is effective and well tolerated in patients with relapsed or refractory B cell non-Hodgkin's lymphoma.
