Clinical analysis of the current treatment status of gastric cancer in 636 patients.
- Author:
Qing-xin ZHUANG
1
;
Jian-ming XU
;
Li LIN
;
Fei-jiao GE
;
Lie-Jun LIU
;
Yan WANG
;
Chuan-hua ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; pathology; surgery; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; therapeutic use; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Carcinoma, Signet Ring Cell; drug therapy; pathology; surgery; Chemotherapy, Adjuvant; China; Cisplatin; administration & dosage; Disease-Free Survival; Female; Gastrectomy; methods; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; administration & dosage; Paclitaxel; administration & dosage; Retrospective Studies; Salvage Therapy; Stomach Neoplasms; drug therapy; pathology; surgery; Survival Rate; Trastuzumab; Young Adult
- From: Chinese Journal of Oncology 2012;34(4):316-320
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the current clinical treatment status of gastric cancer in China.
METHODSA retrospective analysis of clinicopathological characteristics of 636 patients with gastric cancer was conducted. Tumor response was evaluated using RECIST version 1.1 criteria.
RESULTSSix hundred and thirty-six patients were included in this retrospective cohort: 479 men and 157 women. The median age was 57 years (14 to 86). The tumor site was: proximal (41.4%), distal (46.4%) or unknown (12.2%). The histology was: adenocarcinoma (85.8%), signet ring cell carcinoma (6.9%), or other and unknown (7.2%). The differentiation of the adenocarcinomas was: well differentiated (31.0%), moderately differentiated (13.4%), poorly differentiated (37.0%), or unknown (18.7%). The pTNM stage was: 0 (0.3%), I (3.6%), II (10.1%), III (36.8%), IV (45.6%), or unknown (3.6%). In 284 patients who underwent radical resection, the ratio of examined ten and/or more lymph nodes was higher in hospitals at or above provincial level than in hospitals at regional level (57.9% vs. 39.6%, P = 0.009). The disease-free survival was longer (21.7 m vs. 14.6 m, P = 0.005), and the overall survival was longer too (52.9 m vs. 33.8 m, P = 0.040). In 205 patients who received adjuvant chemotherapy, the ratio of administered six and/or more cycles chemotherapy was 42.1% vs. 35.2% (P = 0.318), and the disease-free survival was 22.7 m vs. 16.3 m (P = 0.005) between hospitals at or above provincial level and hospitals at regional level. In 387 patients with metastatic or unresectable gastric cancer who received palliative chemotherapy, the overall survival was 11.1 m (95%CI 9.9 - 12.3 m). Among them, 198 patients received second and/or more line chemotherapy, and the overall survival was longer (12.5 m vs. 7.7 m, P < 0.001). Except a longer progression-free survival (10.2 m, P < 0.05) and a longer overall survival (16.9 m, P < 0.05) were corresponded with the regimen containing trastuzumab, no other significant difference was observed among regimens in first line chemotherapy.
CONCLUSIONChinese doctors working in different level hospitals have a different understanding of the treatment standard of gastric cancer, which resulted in different outcomes.
